The study found that episodes of sustained elevated ICP were associated with a concomitant decrease in NPi in subjects with intracranial hypertension. Critical Care published a study examining the relationship between the NPi and invasive intracranial pressure (ICP) in 54 patients with severe traumatic brain injury (TBI).Another study in Neurocritical Care found that abnormal NPi and pupillary light reflex measurements by pupillometer are predictive of poor outcomes very early after resuscitation from cardiac arrest, and are not usually associated with dilated pupils.The study provided a greater understanding of expected distributions for automated pupillometry values in a wide range of neurocritical care populations. Data published in the Journal of Neuroscience Nursing demonstrated significant differences in pupillary values for NPi, latency, and constriction velocity when stratified by age, sex, or severity of illness defined by the Glasgow Coma Scale score.A study published in Neurocritical Care found that automated pupillometry is more reliable than standard clinical assessments in detecting and tracking subtle changes in cerebral edema and pupillary reactivity during osmotic therapy.
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